With his An Interpretation of Nietzsche's "On the Uses and Disadvantage of History for Life", Anthony K. Jensen shows how 'timely' Nietzsche's second "Untimely Meditation" really is. This comprehensive and insightful study contextualizes and analyzes a wide range of Nietzsche's earlier thoughts about history: teleology, typology, psychology, memory, classical philology, Hegelianism, and the role historiography plays in modern culture. On the Uses and Disadvantage of History for Life is shown to be a 'timely' work, too, insofar as it weaves together a number of Nietzsche's most important influences and thematic directions at that time: ancient culture, science, epistemology, and the thought of Schopenhauer and Burckhardt. Rather than dismiss it as a mere 'early' work, Jensen shows how the text resonates in Nietzsche's later perspectivism, his theory of subjectivity, and Eternal Recurrence. And by using careful philological analysis of the text's composition history, Jensen is in position to fully elucidate and evaluate Nietzsche's arguments in their proper contexts. As such Jensen's Interpretation should restore Nietzsche's second "Untimely Meditation" to a prominent place among 19th Century philosophies of history.

With his An Interpretation of Nietzsche's "On the Uses and Disadvantage of History for Life", Anthony K. Jensen shows how 'timely' Nietzsche's second "Untimely Meditation" really is. This comprehensive and insightful study contextualizes and analyzes a wide range of Nietzsche's earlier thoughts about history: teleology, typology, psychology, memory, classical philology, Hegelianism, and the role historiography plays in modern culture. On the Uses and Disadvantage of History for Life is shown to be a 'timely' work, too, insofar as it weaves together a number of Nietzsche's most important influences and thematic directions at that time: ancient culture, science, epistemology, and the thought of Schopenhauer and Burckhardt. Rather than dismiss it as a mere 'early' work, Jensen shows how the text resonates in Nietzsche's later perspectivism, his theory of subjectivity, and Eternal Recurrence. And by using careful philological analysis of the text's composition history, Jensen is in position to fully elucidate and evaluate Nietzsche's arguments in their proper contexts. As such Jensen's Interpretation should restore Nietzsche's second "Untimely Meditation" to a prominent place among 19th Century philosophies of history.

Nietzsche, the so-called herald of the 'philosophy of the future', nevertheless dealt with the past on nearly every page of his writing. Not only was he concerned with how past values, cultural practices and institutions influence the present - he was plainly aware that any attempt to understand that influence encounters many meta-historical problems. This comprehensive and lucid exposition of the development of Nietzsche's philosophy of history explores how Nietzsche thought about history and historiography throughout his life and how it affected his most fundamental ideas. Discussion of the whole span of Nietzsche's writings, from his earliest publications as a classical philologist to his later genealogical and autobiographical projects, is interwoven with careful analysis of his own forms of writing history, the nineteenth-century paradigms which he critiqued, and the twentieth-century views which he anticipated. The book will be of much interest to scholars of Nietzsche and of nineteenth-century philosophy.

Nietzsche, the so-called herald of the 'philosophy of the future', nevertheless dealt with the past on nearly every page of his writing. Not only was he concerned with how past values, cultural practices and institutions influence the present - he was plainly aware that any attempt to understand that influence encounters many meta-historical problems. This comprehensive and lucid exposition of the development of Nietzsche's philosophy of history explores how Nietzsche thought about history and historiography throughout his life and how it affected his most fundamental ideas. Discussion of the whole span of Nietzsche's writings, from his earliest publications as a classical philologist to his later genealogical and autobiographical projects, is interwoven with careful analysis of his own forms of writing history, the nineteenth-century paradigms which he critiqued, and the twentieth-century views which he anticipated. The book will be of much interest to scholars of Nietzsche and of nineteenth-century philosophy.

Peptides serve as effective drugs in the clinic today. However the inherent drawbacks of peptide structures can limit their efficacy as drugs. To overcome this researchers are developing new methods to create tailor-made' peptides and proteins with improved pharmacological properties. Design of Peptides and Proteins provides an overview of the experimental and computational methods for peptide and protein design, with an emphasis on specific applications for therapeutics and biomedical research. Topics covered include: * Computer modeling of peptides and proteins * Peptidomimetics * Design and synthesis of cyclic peptides * Carbohydrates in peptide and protein design * De novo design of peptides and proteins * Medical development applications * An extended case study - the design of insulin variants Design of Peptides and Proteins presents the state-of-the-art of this exciting approach for therapeutics, with contributions from international experts. It is an essential resource for academic and industrial scientists in the fields of peptide and protein drug design, biomedicine, biochemistry, biophysics, molecular modelling, synthetic organic chemistry and medicinal/pharmaceutical chemistry.

History and memory rank as central themes in the philosophy of Friedrich Nietzsche. As one of the last philosophers of the 19th century, Nietzsche naturally belongs to the so-called 'historical century'. The contentious exchange with the past and with antiquity - as much as the mechanisms, the dangers, and the lessons of memory and tradition - are continually examined and stand in close relationship with Nietzsche's vision of life and his project of human development. As Jacob Burckhardt once wrote of the cultural critique to his Basel colleague: "Fundamentally, you are always teaching history" (9/13/1882). Following Burckhardt's judgment, the contributors focus on the analysis of core questions in the philosophies of history and memory, and their respective convergence in the thought of Nietzsche. The epistemological relevance of these central concepts will be thematized alongside those concerning tradition, and education. The discussion of these rich themes unifies a broad spectrum of questions, ranging from cultural memory to contemporary philosophy of mind. The contributions are revised versions of selected papers presented at the 2018 conference of the annual meeting of the Nietzsche Society in Naumburg.

Typically, the first decade of Friedrich Nietzsche's career is considered a sort of precis to his mature thinking. Yet his philological articles, lectures, and notebooks on Ancient Greek culture and thought - much of which has received insufficient scholarly attention - were never intended to serve as a preparatory ground to future thought. Nietzsche's early scholarship was intended to express his insights into the character of antiquity. Many of those insights are not only important for better understanding Nietzsche; they remain vital for understanding antiquity today. Interdisciplinary in scope and international in perspective, this volume investigates Nietzsche as a scholar of antiquity, offering the first thorough examination of his articles, lectures, notebooks on Ancient Greek culture and thought in English. With eleven original chapters by some of the leading Nietzsche scholars and classicists from around the world and with reproductions of two definitive essays, this book analyzes Nietzsche's scholarly methods and aims, his understanding of antiquity, and his influence on the history of classical studies.

Wide-ranging essays making up the first major study of Nietzsche and the classical tradition in a quarter of a century. This volume collects a wide-ranging set of essays examining Friedrich Nietzsche's engagement with antiquity in all its aspects. It investigates Nietzsche's reaction and response to the concept of "classicism," with particular reference to his work on Greek culture as a philologist in Basel and later as a philosopher of modernity, and to his reception of German classicism in all his texts. The book should be of interest to students of ancient history and classics, philosophy, comparative literature, and Germanistik. Taken together, these papers suggest that classicism is both a more significant, and a more contested, concept for Nietzsche than is often realized, and it demonstratesthe need for a return to a close attention to the intellectual-historical context in terms of which Nietzsche saw himself operating. An awareness of the rich variety of academic backgrounds, methodologies, and techniques of reading evinced in these chapters is perhaps the only way for the contemporary scholar to come to grips with what classicism meant for Nietzsche, and hence what Nietzsche means for us today. The book is divided into five sections -- The Classical Greeks; Pre-Socratics and Pythagoreans, Cynics and Stoics; Nietzsche and the Platonic Tradition; Contestations; and German Classicism -- and constitutes the first major study of Nietzsche and the classical tradition in a quarter of a century. Contributors: Jessica N. Berry, Benjamin Biebuyck, Danny Praet and Isabelle Vanden Poel, Paul Bishop, R. Bracht Branham, Thomas Brobjer, David Campbell, Alan Cardew, Roy Elveton, Christian Emden, Simon Gillham, John Hamilton, Mark Hammond, Albert Henrichs, Dirk t.D. Held, David F. Horkott, Dylan Jaggard, Fiona Jenkins, Anthony K. Jensen, Laurence Lampert, Nicholas Martin, Thomas A. Meyer, Burkhard Meyer-Sickendiek, John S. Moore, Neville Morley, David N. McNeill, James I. Porter, Martin A. Ruehl, Herman Siemens, Barry Stocker, Friedrich Ulfers and Mark Daniel Cohen, and Peter Yates. Paul Bishop is William Jacks Chair of Modern Languages at the University of Glasgow.

Typically, the first decade of Friedrich Nietzsche's career is considered a sort of precis to his mature thinking. Yet his philological articles, lectures, and notebooks on Ancient Greek culture and thought - much of which has received insufficient scholarly attention - were never intended to serve as a preparatory ground to future thought. Nietzsche's early scholarship was intended to express his insights into the character of antiquity. Many of those insights are not only important for better understanding Nietzsche; they remain vital for understanding antiquity today. Interdisciplinary in scope and international in perspective, this volume investigates Nietzsche as a scholar of antiquity, offering the first thorough examination of his articles, lectures, notebooks on Ancient Greek culture and thought in English. With eleven original chapters by some of the leading Nietzsche scholars and classicists from around the world and with reproductions of two definitive essays, this book analyzes Nietzsche's scholarly methods and aims, his understanding of antiquity, and his influence on the history of classical studies.

Most honeymoons, Mary knows, do not start this way. Lying outside on the sloping attic roof in Edinburgh, listening to the soft snores of her groom, she realizes that Rudy's number one rule, "adapt," once again reigns. Rudy's Rules for Travel takes you across the twentieth-century globe with intrepid, frugal Rudy and his spouse Mary, a catastrophic thinker seeking comfort. Whether stalled in a Spanish car tunnel, stranded atop a runaway elephant, or held at rifle-point at a Soviet border, Rudy has a rule for every occasion-for example, "Relax, some kind stranger will appear." Mary, meanwhile, has her deep breathing and her own commandment: "Expect the worst." The two are a picture of contrast. As Mary was being born, Rudy was a new American citizen flying US Air Force missions over his homeland, Germany. His father was a seaman, hers an accountant. And when this marriage of opposites goes traveling, their stories combine laugh-out-loud humor with poignant lessons from the odyssey of a World War II veteran. So start packing-you'll want to join these two.

Political science is becoming ever more reliant on abstract statistical models and almost divorced from human judgment, hope, and idealism. William Shakespeare offers the political scientist an antidote to this methodological alienation, this self-imposed exile from the political concerns of citizens and politicians. Shakespeare, the most quoted author in the English-speaking world, presents his characters as rulers, citizens, and statesmen of the most famous regimes, governed by their respective laws and shaped by their respective political and social institutions. The actions, deliberations, mistakes, and successes of his characters reveal the limitations and strengths of their regimes, whether they be Athens, Rome, or England. The contributors to this volume, esteemed scholars of political science, show us that Shakespeare's poetic imagination displays the very essence of politics and inspires valuable reflection on the fundamental questions of statesmanship and political leadership. Perspectives on Shakespeare's Politics explores such themes as classical republicanism and liberty, the rule of law and morality, the nature and limits of statesmanship, and the character of democracy.

Political science is becoming ever more reliant on abstract statistical models and almost divorced from human judgment, hope, and idealism. William Shakespeare offers the political scientist an antidote to this methodological alienation, this self-imposed exile from the political concerns of citizens and politicians. Shakespeare, the most quoted author in the English-speaking world, presents his characters as rulers, citizens, and statesmen of the most famous regimes, governed by their respective laws and shaped by their respective political and social institutions. The actions, deliberations, mistakes, and successes of his characters reveal the limitations and strengths of their regimes, whether they be Athens, Rome, or England. The contributors to this volume, esteemed scholars of political science, show us that Shakespeare's poetic imagination displays the very essence of politics and inspires valuable reflection on the fundamental questions of statesmanship and political leadership. Perspectives on Shakespeare's Politics explores such themes as classical republicanism and liberty, the rule of law and morality, the nature and limits of statesmanship, and the character of democracy.

Literary works, through their very personal means of characterization, reveal the direct effect of politics on individuals in a way a political treatise cannot. The distinguished contributors to this volume share the belief that Shakespeare is the author who most effectively sets forth the multifarious pageant of politics. Shakespeare's rich canon presents monarchy and republic, tyrant and king, thinker and soldier, and Christian and pagan. The twelve essays in Shakespeare's Political Pageant discuss a broad range of Shakespeare's dramatic poetry from the perspective of the political theorist. This innovative book demonstrates the immense value of seeing Shakespeare's plays in the context of political philosophy. It will be an important source for students and scholars of both political science and literature.